Though Monk ended years before the COVID-19 Pandemic, we still know what happened to Adrian (Tony Shalhoub) while he was in quarantine. Adrian Monk is probably the best-known germaphobe in television history. While Adrian's OCD and agoraphobia are generally played for laughs, there were also some truly heartbreaking episodes of Monk that examined his mental health struggles in detail. While many of his problems went away after Monk solved Trudy's murder, many fans of the detective procedural likely want to know how Adrian would have fared when all of his fears of germs were vindicated in the COVID-19 Pandemic.