Several notable Monk characters were missing from Mr. Monk's Last Case: A Monk Movie for an important reason. Tony Shalhoub returned to play Adrian Monk, showing what happened to the beloved detective after the height of the Covid-19 pandemic, and as he took on a deeply personal case. Other returning characters in Mr. Monk's Last Case included Ted Levine as Leland Stottlemeyer, Traylor Howard as Natalie Teeger, Jason Gray-Stanford as Randy Disher, Melora Hardin as Trudy Monk, and Héctor Elizondo as Dr. Neven Bell.