One of the stars of House pointed to one of the show's darkest episodes as his favorite, and also said that it presented a difficult acting challenge. Over the eight seasons of House, the titular doctor, played by Hugh Laurie, investigated a wide range of diseases and illnesses with his semi-rotating diagnostic team. House is a mystery-of-the-week type of show with season-long and even multiseason-long storylines coming into play over the course of the show. Not every episode is critical in the grand scheme of the series, but there are some that reshape the show forever after.
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