Once you reach Act 2 of Clair Obscur: Expedition 33 and leave Old Lumiere, you'll have to decide which Axon enemy you want to fight first before going on to try to destroy the Paintress. Players will have the option to fight either Visages or Sirene, two main Axon bosses located on different islands accessible in Act 2. You'll have to fight both of them eventually if you want to advance the main story, and while both bosses pose a unique challenge, there's a recommended order to take them on in terms of difficulty level.