Players warned over deadly Las Vegas drug

NRL boss Andrew Abdo is confident players will heed a warning over deadly drug fentanyl during the trip to Las Vegas.

A top police officer from the famed American city addressed all four clubs - Brisbane, Manly, South Sydney, and the Roosters - before their arrival this week.

Among his advice was a warning over fentanyl, which is a synthetic drug used by doctors to treat severe pain.

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It's said to be up to 100 times more potent that heroin and can be deadly if ingested in the wrong manner.

"We're fully aware, those risks exist here in Australia, they exist anywhere around the world," Abdo told Nine's Today on Friday.

"It's not a major concern for us.

"The main thing was to ensure that everyone who's travelling - players, fans, officials - are well educated and understand the risks of travelling overseas in any environment.

"The players are well informed, they are professionals. They're in camps, all four teams have arrived safely and they're hard at work training."

The NRL is desperate for players to be on their best behaviour during the league's inaugural foray into the American sporting market.

Already a number of stars had to front the US embassy in Sydney in order to get permission to fly to the States, given past legal trouble.

Broncos captains Adam Reynolds and Patrick Carrigan put their trips in jeopardy when they were filmed drunkenly wrestling only a week before flying out.

The last thing the NRL - and commission chairman Peter V'landys - wants is to be embarrassed on the international stage by any off-field indiscretions in Sin City.

But the players have been briefed and Abdo is confident it will be smooth sailing.

"There's risks associated with any major event, (and) we've taken the necessary precautions to mitigate those risks," he said.

"The players are professionals, and we've seen the last few years unbelievable role modelling from the players.

"They take their job really seriously, they train really hard.

"There is also genuine excitement among the playing group for this opportunity... I'm not concerned at all."

The NRL double header in Las Vegas will be played on Sunday, March 3 (AEDT).