NFL Week 6: Hurts and Jackson Ruled Out as QB Injuries Reshape Matchups

The NFL Week 6 slate has been dramatically reshaped by high-profile quarterback injuries and significant roster shifts. Both the Philadelphia Eagles and Baltimore Ravens will take the field on Sunday without their franchise signal-callers, forcing oddsmakers to pivot and fantasy managers to scramble for depth chart replacements.

The most impactful development involves Eagles quarterback Jalen Hurts, who has been ruled out for Week 6 due to a blood clot in his calf. Tanner McKee is scheduled to make the start in his place. This medical update caused a massive swing in the betting markets; Philadelphia opened the week as a favorite but has since shifted to a 3-point underdog against the Carolina Panthers.

Tanner McKee is set to start for the Eagles as the team manages ' medical absence.

The Baltimore Ravens face a similar hurdle as they prepare for a divisional clash against the Cleveland Browns. Lamar Jackson is confirmed out with an ankle injury, meaning Tyler Huntley will earn the start. Analysis suggests the Ravens will likely rely more heavily on their ground game to support Huntley against a stout Browns defensive front.

Thursday Night Football Recap

The Week 6 action began with a defensive battle in Denver. The Broncos defeated the Seattle Seahawks 17-14 in overtime on October 15. The victory provides Denver with crucial momentum in the AFC West, while the Seahawks fall back in the NFC West race after the narrow road loss.

International Series: Texans vs. Jaguars

The NFL returns to London this Sunday for a 9:30 a.m. ET kickoff between the Houston Texans and the Jacksonville Jaguars. A major storyline for Houston is the status of Marvin Harrison Jr., who is confirmed active for this matchup. Harrison Jr. is expected to play in specific packages, providing C.J. Stroud with a high-upside target in the international spotlight.

Veteran Leadership and the Search for Win One

In Tampa Bay, Aaron Rodgers continues his campaign as the starting quarterback for the Pittsburgh Steelers. Following the Buccaneers’ first win of the season last week, Rodgers faces a defensive unit looking to build a streak. Performance analysis indicates the Steelers’ offensive rhythm will depend heavily on Rodgers’ ability to manage the pocket against a surging Bucs pass rush.

Pressure is also mounting for the Tennessee Titans and the Los Angeles Chargers. Both franchises enter Week 6 still seeking their first victories of the 2026 season. Avoiding an 0-6 start is the primary objective for both clubs as they navigate critical mid-season adjustments.

The Texans and Jaguars prepare for an early morning kickoff at the NFL's latest London appearance.

Sunday Night Football and Week 6 Byes

The prime-time Sunday window features the Green Bay Packers traveling to face the Dallas Cowboys. Despite the home-field advantage for Dallas, the Packers are currently 1-point favorites. This narrow spread reflects the inconsistent play from both teams over the first five weeks of the season.

Four teams are on bye this week, removing several high-powered offenses from the Sunday schedule:

Cincinnati Bengals Detroit Lions Miami Dolphins Minnesota Vikings

With the Vikings on a bye, the San Francisco 49ers and Minnesota remain the only two undefeated teams in the league. The 49ers have the opportunity to move to 6-0 if they can secure a win during the Sunday afternoon slate.

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