mRNA immunotherapy developed by UMass Chan scientists eliminates pancreatic tumors in mice

Inspired by the work of the RNA Therapeutics Institute at UMass Chan Medical School and the development of the COVID vaccine, Marcus Ruscetti, PhD, and Chaitanya Naimesh Parikh, PhD’26, have developed an immunotherapy using a cocktail of messenger RNAs (mRNA) that could potentially be transformative for pancreatic cancer treatment. The study, published in Nature Communications, combines immune cytokine and tumor-associated antigen mRNAs into a single injection to treat pancreatic ductal adenocarcinoma. Approximately 50 percent of mice with pancreatic cancer treated with the mRNA immunotherapeutic cocktail saw complete tumor responses and more impressively, remained disease free for a year, even after...