8 Most Upsetting Departures In Grey's Anatomy History

Over the course of the two decades it’s been on, Grey's Anatomy has lost more than its fair share of key characters, but some departures have stung more than others, for how abruptly they happened or how their consequences changed the medical drama. With only three original characters still consistently part of Grey’s Anatomy’s central story, more characters left than those who stayed at Grey Sloan Memorial. With Grey’s Anatomy becoming known for killing off its main characters, some of its most upsetting departures involved key characters brutally dying, or doing so gratuitously, as their exits were already set up.